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The role of SAMHD1 expression and its relation to HIV-2 (Vpx) gene production
SAMHD1 (sterile alpha motif and HD domain 1) is a protein that is found in myeloid cells, which restricts HIV1 replication. It depletes the de-oxy-nucleoside tri-phosphate (dNTPs) pool needed for a viral cDNA synthesis leading to inhibition of viral replication inside the cells. However, it does not...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128726/ https://www.ncbi.nlm.nih.gov/pubmed/30202235 http://dx.doi.org/10.1016/j.jsps.2018.03.005 |