Cargando…

Focused clamping of a single neuronal SNARE complex by complexin under high mechanical tension

Neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) catalyze synaptic vesicle fusion with presynaptic membranes through the formation of SNARE complexes. Complexin (Cpx) is the only presynaptic protein that tightly binds to SNAREs and regulates membrane fusion, b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shon, Min Ju, Kim, Haesoo, Yoon, Tae-Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128827/ https://www.ncbi.nlm.nih.gov/pubmed/30194295 http://dx.doi.org/10.1038/s41467-018-06122-3

Ejemplares similares

The Accessory Helix of Complexin Stabilizes a Partially Unzippered State of the SNARE Complex and Mediates the Complexin Clamping Function In Vivo
por: Brady, Joshua, et al.
Publicado: (2021)

Complexin cross-links pre-fusion SNAREs into a zig-zag array: a structure-based model for complexin clamping
por: Kümmel, Daniel, et al.
Publicado: (2011)

Complexin-1 regulated assembly of single neuronal SNARE complex revealed by single-molecule optical tweezers
por: Hao, Tongrui, et al.
Publicado: (2023)

Complexin and Ca(2+) stimulate SNARE-mediated membrane fusion
por: Yoon, Tae-Young, et al.
Publicado: (2008)

Concurrent Binding of Complexin and Synaptotagmin to Liposome-Embedded SNARE Complexes
por: Chicka, Michael C., et al.
Publicado: (2009)

Cell Types and Synapses Expressing the SNARE Complex Regulating Proteins Complexin 1 and Complexin 2 in Mammalian Retina
por: Lux, Uwe Thorsten, et al.
Publicado: (2021)

NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin
por: Choi, Ucheor B, et al.
Publicado: (2018)

Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution
por: Jaczynska, Klaudia, et al.
Publicado: (2022)

Molecular determinants of complexin clamping and activation function
por: Bera, Manindra, et al.
Publicado: (2022)

Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
por: Courtney, Nicholas A., et al.
Publicado: (2019)

Re-visiting the trans insertion model for complexin clamping
por: Krishnakumar, Shyam S, et al.
Publicado: (2015)

Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes
por: Prinslow, Eric A, et al.
Publicado: (2017)

Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin
por: Zhang, Yunxiang, et al.
Publicado: (2015)

Correction: Re-visiting the trans insertion model for complexin clamping
por: Krishnakumar, Shyam S, et al.
Publicado: (2017)

Stabilization of the SNARE Core by Complexin-1 Facilitates Fusion Pore Expansion
por: Pierson, Josh, et al.
Publicado: (2021)

Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex
por: Choi, Ucheor B, et al.
Publicado: (2016)

Complexin-1 Enhances the On-Rate of Vesicle Docking via Simultaneous SNARE and Membrane Interactions
por: Diao, Jiajie, et al.
Publicado: (2013)

Extreme parsimony in ATP consumption by 20S complexes in the global disassembly of single SNARE complexes
por: Kim, Changwon, et al.
Publicado: (2021)

Involvement of Complexin 2 in Docking, Locking and Unlocking of Different SNARE Complexes during Sperm Capacitation and Induced Acrosomal Exocytosis
por: Tsai, Pei-Shiue J., et al.
Publicado: (2012)

All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer
por: Rizo, Josep, et al.
Publicado: (2022)

Complexins: small but capable
por: Mohrmann, Ralf, et al.
Publicado: (2015)

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability
por: Robinson, Susan W., et al.
Publicado: (2018)

Stochastic RNA editing of the Complexin C-terminus within single neurons regulates neurotransmitter release
por: Brija, Elizabeth A., et al.
Publicado: (2023)

Stochastic RNA editing of the Complexin C-terminus within single neurons regulates neurotransmitter release
por: Brija, Elizabeth A., et al.
Publicado: (2023)

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
por: Ramakrishnan, Sathish, et al.
Publicado: (2020)

Real-Time Visualization of Complexin During Single Exocytic Events
por: An, Seong J., et al.
Publicado: (2010)

Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins
por: Wragg, Rachel T., et al.
Publicado: (2017)

Complexin in ivermectin resistance in body lice
por: Amanzougaghene, Nadia, et al.
Publicado: (2018)

A mechanism for exocytotic arrest by the Complexin C-terminus
por: Makke, Mazen, et al.
Publicado: (2018)

Mechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanism
por: Min, Duyoung, et al.
Publicado: (2013)

A Role for the V0 Sector of the V-ATPase in Neuroexocytosis: Exogenous V0d Blocks Complexin and SNARE Interactions with V0c
por: Lévêque, Christian, et al.
Publicado: (2023)

Helical extension of the neuronal SNARE complex into the membrane
por: Stein, Alexander, et al.
Publicado: (2009)

Structural basis for the clamping and Ca(2+) activation of SNARE-mediated fusion by synaptotagmin
por: Grushin, Kirill, et al.
Publicado: (2019)

Membrane-directed molecular assembly of the neuronal SNARE complex
por: Cho, Won Jin, et al.
Publicado: (2011)

Structurally and functionally unique complexins at retinal ribbon synapses
por: Reim, Kerstin, et al.
Publicado: (2005)

Re-examining how complexin inhibits neurotransmitter release
por: Trimbuch, Thorsten, et al.
Publicado: (2014)

Membrane curvature sensing by the C-terminal domain of complexin
por: Snead, David, et al.
Publicado: (2014)

Expression of Concern: Complexin in ivermectin resistance in body lice
Publicado: (2022)

Patch clamp-assisted single neuron lipidomics
por: Merrill, Collin B., et al.
Publicado: (2017)

Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development
por: Zanazzi, George, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_2onen254d095hc3l1gv2m4qbd2