Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration

Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease caused by expansion of polyglutamine tract in the ATXN2 protein. We identified Staufen1 (STAU1) as an interactor of ATXN2, and showed elevation in cells from SCA2 patients, amyotrophic lateral sclerosis (ALS) patients, and in SCA2 m...

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Detalles Bibliográficos
Autores principales: Paul, Sharan, Dansithong, Warunee, Figueroa, Karla P., Scoles, Daniel R., Pulst, Stefan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128856/
https://www.ncbi.nlm.nih.gov/pubmed/30194296
http://dx.doi.org/10.1038/s41467-018-06041-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128856/
https://www.ncbi.nlm.nih.gov/pubmed/30194296
http://dx.doi.org/10.1038/s41467-018-06041-3

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