Genetic screen in myeloid cells identifies TNF-α autocrine secretion as a factor increasing MDSC suppressive activity via Nos2 up-regulation

The suppressive microenvironment of tumors remains one of the limiting factors for immunotherapies. In tumors, the function of effector T cells can be inhibited by cancer cells as well as myeloid cells including tumor associated macrophages and myeloid-derived suppressor cells (MDSC). A better under...

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Detalles Bibliográficos
Autores principales: Schröder, Matthias, Krötschel, Marit, Conrad, Lena, Naumann, Svenja Kerstin, Bachran, Christopher, Rolfe, Alex, Umansky, Viktor, Helming, Laura, Swee, Lee Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128861/
https://www.ncbi.nlm.nih.gov/pubmed/30194424
http://dx.doi.org/10.1038/s41598-018-31674-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128861/
https://www.ncbi.nlm.nih.gov/pubmed/30194424
http://dx.doi.org/10.1038/s41598-018-31674-1

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