Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1

Nitro-substituted 1,3-benzothiazinones (nitro-BTZs) are mechanism-based covalent inhibitors of Mycobacterium tuberculosis decaprenylphosphoryl-β-D-ribose-2′-oxidase (DprE1) with strong antimycobacterial properties. We prepared a number of oxidized and reduced forms of nitro-BTZs to probe the mechani...

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Detalles Bibliográficos
Autores principales: Richter, Adrian, Rudolph, Ines, Möllmann, Ute, Voigt, Kerstin, Chung, Chun-wa, Singh, Onkar M. P., Rees, Michael, Mendoza-Losana, Alfonso, Bates, Robert, Ballell, Lluís, Batt, Sarah, Veerapen, Natacha, Fütterer, Klaus, Besra, Gurdyal, Imming, Peter, Argyrou, Argyrides
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128881/
https://www.ncbi.nlm.nih.gov/pubmed/30194385
http://dx.doi.org/10.1038/s41598-018-31316-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128881/
https://www.ncbi.nlm.nih.gov/pubmed/30194385
http://dx.doi.org/10.1038/s41598-018-31316-6

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