Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits

Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-analysis of two genome-wide association studies of leiomyoma in European women (16,595 cases and 523,330 controls), uncovering 21 variants at 16 loci that associate with the disease. Five variants were previously repo...

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Detalles Bibliográficos
Autores principales: Rafnar, Thorunn, Gunnarsson, Bjarni, Stefansson, Olafur A., Sulem, Patrick, Ingason, Andres, Frigge, Michael L., Stefansdottir, Lilja, Sigurdsson, Jon K., Tragante, Vinicius, Steinthorsdottir, Valgerdur, Styrkarsdottir, Unnur, Stacey, Simon N., Gudmundsson, Julius, Arnadottir, Gudny A., Oddsson, Asmundur, Zink, Florian, Halldorsson, Gisli, Sveinbjornsson, Gardar, Kristjansson, Ragnar P., Davidsson, Olafur B., Salvarsdottir, Anna, Thoroddsen, Asgeir, Helgadottir, Elisabet A., Kristjansdottir, Katrin, Ingthorsson, Orri, Gudmundsson, Valur, Geirsson, Reynir T., Arnadottir, Ragnheidur, Gudbjartsson, Daniel F., Masson, Gisli, Asselbergs, Folkert W., Jonasson, Jon G., Olafsson, Karl, Thorsteinsdottir, Unnur, Halldorsson, Bjarni V., Thorleifsson, Gudmar, Stefansson, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128903/
https://www.ncbi.nlm.nih.gov/pubmed/30194396
http://dx.doi.org/10.1038/s41467-018-05428-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128903/
https://www.ncbi.nlm.nih.gov/pubmed/30194396
http://dx.doi.org/10.1038/s41467-018-05428-6

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