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Use of a temporary immersion bioreactor system for the sustainable production of thapsigargin in shoot cultures of Thapsia garganica

BACKGROUND: Thapsigargin and nortrilobolide are sesquiterpene lactones found in the Mediterranean plant Thapsia garganica L. Thapsigargin is a potent inhibitor of the sarco/endoplasmic reticulum calcium ATPase pump, inducing apoptosis in mammalian cells. This mechanism has been used to develop a tha...

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Detalles Bibliográficos
Autores principales:	López, Carmen Quiñonero, Corral, Patricia, Lorrain-Lorrette, Bénédicte, Martinez-Swatson, Karen, Michoux, Franck, Simonsen, Henrik Toft
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128993/ https://www.ncbi.nlm.nih.gov/pubmed/30202426 http://dx.doi.org/10.1186/s13007-018-0346-z

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