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The Structural Basis of IKs Ion-Channel Activation: Mechanistic Insights from Molecular Simulations

Relating ion channel (iCh) structural dynamics to physiological function remains a challenge. Current experimental and computational techniques have limited ability to explore this relationship in atomistic detail over physiological timescales. A framework associating iCh structure to function is ne...

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Detalles Bibliográficos
Autores principales: Ramasubramanian, Smiruthi, Rudy, Yoram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129186/
https://www.ncbi.nlm.nih.gov/pubmed/29874609
http://dx.doi.org/10.1016/j.bpj.2018.04.023