Cargando…

De novo NAD+ biosynthetic impairment in acute kidney injury in humans

Nicotinamide adenine dinucleotide (NAD+) extends longevity in experimental organisms, raising interest in its impact on human health. De novo NAD+ biosynthesis from tryptophan is evolutionarily conserved yet considered supplanted among higher species by biosynthesis from nicotinamide (Nam). Here we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mehr, Ali Poyan, Tran, Mei T., Ralto, Kenneth M., Leaf, David E., Washco, Vaughan, Messmer, Joseph, Lerner, Adam, Kher, Ajay, Kim, Steven H., Khoury, Charbel C., Herzig, Shoshana J., Trovato, Mary E., Simon-Tillaux, Noemie, Lynch, Matthew R., Thadhani, Ravi I., Clish, Clary B., Khabbaz, Kamal R., Rhee, Eugene P., Waikar, Sushrut S., Berg, Anders H., Parikh, Samir M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129212/ https://www.ncbi.nlm.nih.gov/pubmed/30127395 http://dx.doi.org/10.1038/s41591-018-0138-z

Ejemplares similares

NAD(+) homeostasis in renal health and disease
por: Ralto, Kenneth M., et al.
Publicado: (2019)

Metabolic Profiling of Alternative NAD Biosynthetic Routes in Mouse Tissues
por: Mori, Valerio, et al.
Publicado: (2014)

Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients
por: Leaf, David E, et al.
Publicado: (2015)

The key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions
por: Fortunato, Carlo, et al.
Publicado: (2021)

PGC1α-dependent NAD biosynthesis links oxidative metabolism to renal protection
por: Tran, Mei T., et al.
Publicado: (2016)

Nuclear NAD(+)-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons
por: Sokolov, David, et al.
Publicado: (2021)

Time to Expand Access and Utilization of Home Dialysis: Lessons From the COVID-19 Pandemic
por: Stern, Lauren D., et al.
Publicado: (2020)

Plasma FGF23 levels increase rapidly after acute kidney injury
por: Christov, Marta, et al.
Publicado: (2013)

Cross-sectional examination of metabolites and metabolic phenotypes in uremia
por: Kalim, Sahir, et al.
Publicado: (2015)

NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy
por: Rossi, Francesca, et al.
Publicado: (2018)

NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer
por: Audrito, Valentina, et al.
Publicado: (2019)

Hepatocyte-specific perturbation of NAD(+) biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis–like phenotypes
por: Dall, Morten, et al.
Publicado: (2021)

Metabolomics: an emerging but powerful tool for precision medicine
por: Clish, Clary B.
Publicado: (2015)

Excessive diagnostic testing in acute kidney injury
por: Leaf, David E., et al.
Publicado: (2016)

Performance of the Automated Urinalysis in Diagnosis of Proliferative Glomerulonephritis
por: Palsson, Ragnar, et al.
Publicado: (2019)

Evaluating the feasibility of the KDIGO CKD referral recommendations
por: Singh, Karandeep, et al.
Publicado: (2017)

Glomerular Disease Education Experience across Nephrology Fellowship Programs: An International Survey
por: Seethapathy, Harish, et al.
Publicado: (2021)

Prescribing Patterns for Sodium-Glucose Cotransporter 2 Inhibitors: A Survey of Nephrologists
por: Singh, Tripti, et al.
Publicado: (2023)

Limiting positive end-expiratory pressure to protect renal function in SARS-CoV-2 critically ill patients
por: Beurton, Alexandra, et al.
Publicado: (2020)

Severe hyponatremia due to surreptitious water intoxication in a hospitalized patient
por: Claudel, Sophie E., et al.
Publicado: (2022)

A methodological review with meta-epidemiological analysis of preclinical systematic reviews with meta-analyses
por: Simon-Tillaux, Noémie, et al.
Publicado: (2022)

Nephrology co-management versus primary care solo management for early chronic kidney disease: a retrospective cross-sectional analysis
por: Samal, Lipika, et al.
Publicado: (2015)

Novel NAD(+)-Farnesal Dehydrogenase from Polygonum minus Leaves. Purification and Characterization of Enzyme in Juvenile Hormone III Biosynthetic Pathway in Plant
por: Seman-Kamarulzaman, Ahmad-Faris, et al.
Publicado: (2016)

A Plasma Long‐Chain Acylcarnitine Predicts Cardiovascular Mortality in Incident Dialysis Patients
por: Kalim, Sahir, et al.
Publicado: (2013)

Needle Size and the Risk of Kidney Biopsy Bleeding Complications
por: Cui, Salena, et al.
Publicado: (2016)

Dietary Oxalate Intake and Kidney Outcomes
por: Bargagli, Matteo, et al.
Publicado: (2020)

Caring for Dialysis Patients in a Time of COVID-19
por: Verma, Ashish, et al.
Publicado: (2020)

COVID-19 Infection Risk Among Hemodialysis Patients in Long-term Care Facilities
por: Liu, Christine K., et al.
Publicado: (2020)

Machine Learning Applications in Nephrology: A Bibliometric Analysis Comparing Kidney Studies to Other Medicine Subspecialities
por: Verma, Ashish, et al.
Publicado: (2021)

Kidney Disease–Related Mortality Among Asian Americans
por: Claudel, Sophie E., et al.
Publicado: (2023)

“NAD-capQ” detection and quantitation of NAD caps
por: Grudzien-Nogalska, Ewa, et al.
Publicado: (2018)

Chromogranin A Tubulopathy: Differing Histopathologic Patterns of Acute Tubular Injury in the Setting of Neuroendocrine Neoplasms
por: Sekulic, Miroslav, et al.
Publicado: (2019)

A novel antibody for the detection of alternatively spliced secreted KLOTHO isoform in human plasma
por: Jadhav, Shreyas, et al.
Publicado: (2021)

Nephrologists’ Attitudes Toward Native Kidney Biopsy: A Qualitative Study
por: Amodu, Afolarin, et al.
Publicado: (2021)

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis
por: Sharma, Ritu, et al.
Publicado: (2023)

Cloning and Organelle Expression of Bamboo Mitochondrial Complex I Subunits Nad1, Nad2, Nad4, and Nad5 in the Yeast Saccharomyces cerevisiae
por: Tsai, Hsieh-Chin, et al.
Publicado: (2022)

NAD to the rescue
por: Tuma, Rabiya S.
Publicado: (2005)

NAD-seq for profiling the NAD(+) capped transcriptome of Arabidopsis thaliana
por: Yu, Xiang, et al.
Publicado: (2021)

NAD(+) Homeostasis and NAD(+)-Consuming Enzymes: Implications for Vascular Health
por: Campagna, Roberto, et al.
Publicado: (2023)

Uric Acid and Acute Kidney Injury in the Critically Ill
por: Srivastava, Anand, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_sbm5cv5s31gdfhcdvm5k797mua