Development of a gut microbe-targeted non-lethal therapeutic to inhibit thrombosis potential

Trimethylamine-N-oxide (TMAO), a microbiota-dependent metabolite derived from trimethylamine (TMA)-containing nutrients that are abundant in a Western diet, enhances both platelet responsiveness and in vivo thrombosis potential in animal models and predicts incident atherothrombotic event risks in c...

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Detalles Bibliográficos
Autores principales: Roberts, Adam B., Gu, Xiaodong, Buffa, Jennifer A., Hurd, Alex G., Wang, Zeneng, Zhu, Weifei, Gupta, Nilaksh, Skye, Sarah M., Cody, David B., Levison, Bruce S., Barrington, William T., Russel, Matthew W., Reed, Jodie M., Duzan, Ashraf, Lang, Jennifer M., Fu, Xiaoming, Li, Lin, Myers, Alex J., Rachakonda, Suguna, DiDonato, Joseph A., Brown, J. Mark, Gogonea, Valentin, Lusis, Aldons J., Garcia-Garcia, Jose Carlos, Hazen, Stanley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129214/
https://www.ncbi.nlm.nih.gov/pubmed/30082863
http://dx.doi.org/10.1038/s41591-018-0128-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129214/
https://www.ncbi.nlm.nih.gov/pubmed/30082863
http://dx.doi.org/10.1038/s41591-018-0128-1

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