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Off-target predictions in CRISPR-Cas9 gene editing using deep learning

MOTIVATION: The prediction of off-target mutations in CRISPR-Cas9 is a hot topic due to its relevance to gene editing research. Existing prediction methods have been developed; however, most of them just calculated scores based on mismatches to the guide sequence in CRISPR-Cas9. Therefore, the exist...

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Detalles Bibliográficos
Autores principales: Lin, Jiecong, Wong, Ka-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129261/
https://www.ncbi.nlm.nih.gov/pubmed/30423072
http://dx.doi.org/10.1093/bioinformatics/bty554