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Off-target predictions in CRISPR-Cas9 gene editing using deep learning
MOTIVATION: The prediction of off-target mutations in CRISPR-Cas9 is a hot topic due to its relevance to gene editing research. Existing prediction methods have been developed; however, most of them just calculated scores based on mismatches to the guide sequence in CRISPR-Cas9. Therefore, the exist...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129261/ https://www.ncbi.nlm.nih.gov/pubmed/30423072 http://dx.doi.org/10.1093/bioinformatics/bty554 |