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Understanding the evolution of functional redundancy in metabolic networks

MOTIVATION: Metabolic networks have evolved to reduce the disruption of key metabolic pathways by the establishment of redundant genes/reactions. Synthetic lethals in metabolic networks provide a window to study these functional redundancies. While synthetic lethals have been previously studied in d...

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Detalles Bibliográficos
Autores principales: Sambamoorthy, Gayathri, Raman, Karthik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129275/
https://www.ncbi.nlm.nih.gov/pubmed/30423058
http://dx.doi.org/10.1093/bioinformatics/bty604