Bone-Targeted Alkaline Phosphatase Treatment of Mandibular Bone and Teeth in Lethal Hypophosphatasia via an scAAV8 Vector

Hypophosphatasia is an inherited disease caused by mutations in the gene encoding tissue-nonspecific alkaline phosphatase (TNALP), the major symptom of which is hypomineralization of the bones and teeth. We had recently demonstrated that TNALP-deficient (Akp2(−/−)) mice, which mimic the phenotype of...

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Detalles Bibliográficos
Autores principales: Ikeue, Ryo, Nakamura-Takahashi, Aki, Nitahara-Kasahara, Yuko, Watanabe, Atsushi, Muramatsu, Takashi, Sato, Toru, Okada, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129726/
https://www.ncbi.nlm.nih.gov/pubmed/30202773
http://dx.doi.org/10.1016/j.omtm.2018.08.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129726/
https://www.ncbi.nlm.nih.gov/pubmed/30202773
http://dx.doi.org/10.1016/j.omtm.2018.08.004

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