Parkinson’s disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons

BACKGROUND: Parkinson’s disease (PD)-associated E3 ubiquitin ligase Parkin is enriched at glutamatergic synapses, where it ubiquitinates multiple substrates, suggesting that its mutation/loss-of-function could contribute to the etiology of PD by disrupting excitatory neurotransmission. Here, we eval...

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Detalles Bibliográficos
Autores principales: Zhu, Mei, Cortese, Giuseppe P., Waites, Clarissa L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130078/
https://www.ncbi.nlm.nih.gov/pubmed/30200940
http://dx.doi.org/10.1186/s12915-018-0567-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130078/
https://www.ncbi.nlm.nih.gov/pubmed/30200940
http://dx.doi.org/10.1186/s12915-018-0567-7

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