Cargando…
Parkinson’s disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons
BACKGROUND: Parkinson’s disease (PD)-associated E3 ubiquitin ligase Parkin is enriched at glutamatergic synapses, where it ubiquitinates multiple substrates, suggesting that its mutation/loss-of-function could contribute to the etiology of PD by disrupting excitatory neurotransmission. Here, we eval...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130078/ https://www.ncbi.nlm.nih.gov/pubmed/30200940 http://dx.doi.org/10.1186/s12915-018-0567-7 |