Mutational signature distribution varies with DNA replication timing and strand asymmetry

BACKGROUND: DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. Here, we use somatic mutation signatures—each representing a mutagenic process—derived from 3056 patients spanning 19 cancer types to quantify the strand asy...

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Detalles Bibliográficos
Autores principales: Tomkova, Marketa, Tomek, Jakub, Kriaucionis, Skirmantas, Schuster-Böckler, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130095/
https://www.ncbi.nlm.nih.gov/pubmed/30201020
http://dx.doi.org/10.1186/s13059-018-1509-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130095/
https://www.ncbi.nlm.nih.gov/pubmed/30201020
http://dx.doi.org/10.1186/s13059-018-1509-y

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