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Comparative evaluation of Salmonella Typhimurium vaccines derived from UK-1 and 14028S: Importance of inherent virulence

The initial virulence and invasiveness of a bacterial strain may play an important role in leading to a maximally efficacious attenuated live vaccine. Here we show that χ9909, derived from Salmonella Typhimurium UK-1 χ3761 (the most virulent S. Typhimurium strain known to us), is effective in protec...

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Detalles Bibliográficos
Autores principales: Sanapala, Shilpa, Mosca, Leandra, Wang, Shifeng, Curtiss, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130210/
https://www.ncbi.nlm.nih.gov/pubmed/30192849
http://dx.doi.org/10.1371/journal.pone.0203526