Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine

Context: CYP3A4 and P-gp together form a highly efficient barrier for orally absorbed drugs and always share the same substrates. Our previous work revealed that chrysosplenetin (CHR) significantly augmented the rat plasma level and anti-malarial efficacy of artemisinin (ART), partially due to the u...

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Detalles Bibliográficos
Autores principales: Ma, Liping, Wei, Shijie, Yang, Bei, Ma, Wei, Wu, Xiuli, Ji, Hongyan, Sui, Hong, Chen, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130654/
https://www.ncbi.nlm.nih.gov/pubmed/27931149
http://dx.doi.org/10.1080/13880209.2016.1241810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130654/
https://www.ncbi.nlm.nih.gov/pubmed/27931149
http://dx.doi.org/10.1080/13880209.2016.1241810

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