Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro

[Image: see text] A series of chalcone and heterocyclic isosteres, in which the enone moiety was replaced with an isoxazole and pyrazole ring system, was synthesized and their affinities for alpha synuclein (Asyn), amyloid beta (Aβ), and tau fibrils were measured in vitro. The compounds were found t...

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Detalles Bibliográficos
Autores principales: Hsieh, Chia-Ju, Xu, Kuiying, Lee, Iljung, Graham, Thomas J. A., Tu, Zhude, Dhavale, Dhruva, Kotzbauer, Paul, Mach, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130786/
https://www.ncbi.nlm.nih.gov/pubmed/30221226
http://dx.doi.org/10.1021/acsomega.7b01897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130786/
https://www.ncbi.nlm.nih.gov/pubmed/30221226
http://dx.doi.org/10.1021/acsomega.7b01897

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