Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase

Hyperammonemia is the common biochemical hallmark of urea cycle disorders, activating neurotoxic pathways. If untreated, affected individuals have a high risk of irreversible brain damage and mortality. Here we show that acute hyperammonemia strongly enhances transamination-dependent formation of os...

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Detalles Bibliográficos
Autores principales: Zielonka, Matthias, Breuer, Maximilian, Okun, Jürgen Günther, Carl, Matthias, Hoffmann, Georg Friedrich, Kölker, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130883/
https://www.ncbi.nlm.nih.gov/pubmed/30199544
http://dx.doi.org/10.1371/journal.pone.0203707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130883/
https://www.ncbi.nlm.nih.gov/pubmed/30199544
http://dx.doi.org/10.1371/journal.pone.0203707

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