Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology

RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and...

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Detalles Bibliográficos
Autores principales: Zhang, Cai, Seo, Joonbae, Murakami, Kazutoshi, Salem, Esam S. B., Bernhard, Elise, Borra, Vishnupriya J., Choi, Kwangmin, Yuan, Celvie L., Chan, Calvin C., Chen, Xiaoting, Huang, Taosheng, Weirauch, Matthew T., Divanovic, Senad, Qi, Nathan R., Thomas, Hala Einakat, Mercer, Carol A., Siomi, Haruhiko, Nakamura, Takahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131149/
https://www.ncbi.nlm.nih.gov/pubmed/30201950
http://dx.doi.org/10.1038/s41467-018-05870-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131149/
https://www.ncbi.nlm.nih.gov/pubmed/30201950
http://dx.doi.org/10.1038/s41467-018-05870-6

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