Frequent functional activation of RAS signalling not explained by RAS/RAF mutations in relapsed/refractory multiple myeloma

RAS mutations are frequent in relapsed/refractory multiple myeloma (RRMM) but functional study in primary samples is scanty. Herein, in primary myeloma plasma cells of 17 suspected RRMM, functional activation of RAS signalling was studied by Western blot of phosphorylated ERK1/2 (phospho-ERK1/2). Mo...

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Detalles Bibliográficos
Autores principales: Wong, Kwan Yeung, Yao, Qiumei, Yuan, Ling-Qing, Li, Zhenhai, Ma, Edmond Shiu Kwan, Chim, Chor Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131153/
https://www.ncbi.nlm.nih.gov/pubmed/30201956
http://dx.doi.org/10.1038/s41598-018-31820-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131153/
https://www.ncbi.nlm.nih.gov/pubmed/30201956
http://dx.doi.org/10.1038/s41598-018-31820-9

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