The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor

The glucocorticoid receptor (GR) is a steroid hormone receptor of the nuclear receptor family that regulates gene expression in response to glucocorticoid hormone signaling. Interaction with specific GR DNA binding sequences causes conformational changes in the GR DNA binding domain (DBD) that resul...

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Detalles Bibliográficos
Autores principales: Frank, Filipp, Okafor, C. Denise, Ortlund, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131172/
https://www.ncbi.nlm.nih.gov/pubmed/30201977
http://dx.doi.org/10.1038/s41598-018-31812-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131172/
https://www.ncbi.nlm.nih.gov/pubmed/30201977
http://dx.doi.org/10.1038/s41598-018-31812-9

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