Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin

The molecular mechanisms of toxicity and cellular transport of anticancer metallodrugs, including platinum-based agents, have not yet been fully elucidated. The aim of our study was to investigate the relevance of copper transporters (CTR1 and ATP7A/B), organic cation transporters (OCT2) and the mul...

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Detalles Bibliográficos
Autores principales: Spreckelmeyer, Sarah, van der Zee, Margot, Bertrand, Benoît, Bodio, Ewen, Stürup, Stefan, Casini, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131305/
https://www.ncbi.nlm.nih.gov/pubmed/30234099
http://dx.doi.org/10.3389/fchem.2018.00377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131305/
https://www.ncbi.nlm.nih.gov/pubmed/30234099
http://dx.doi.org/10.3389/fchem.2018.00377

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