20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats

We hypothesized that vascular actions of 20-hydroxyeicosatetraenoic acid (20-HETE), the product of cytochrome P450 (CYP450)-dependent ω-hydroxylase, potentiate prohypertensive actions of angiotensin II (ANG II) in Cyp1a1-Ren-2 transgenic rats, a model of ANG II-dependent malignant hypertension. Ther...

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Detalles Bibliográficos
Autores principales: Sedláková, Lenka, Kikerlová, Soňa, Husková, Zuzana, Červenková, Lenka, Chábová, Věra Čertíková, Zicha, Josef, Falck, John R., Imig, John D., Kompanowska-Jezierska, Elzbieta, Sadowski, Janusz, Krátký, Vojtěch, Červenka, Luděk, Kopkan, Libor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131326/
https://www.ncbi.nlm.nih.gov/pubmed/30054426
http://dx.doi.org/10.1042/BSR20171496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131326/
https://www.ncbi.nlm.nih.gov/pubmed/30054426
http://dx.doi.org/10.1042/BSR20171496

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