Super-silent FRET Sensor Enables Live Cell Imaging and Flow Cytometric Stratification of Intracellular Serine Protease Activity in Neutrophils

Serine proteases are released by neutrophils to act primarily as antimicrobial proteins but excessive and unbalanced serine protease activity results in serious host tissue damage. Here the synthesis of a novel chemical sensor based on a multi-branched fluorescence quencher is reported. It is super-...

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Detalles Bibliográficos
Autores principales: Craven, Thomas H., Avlonitis, Nicolaos, McDonald, Neil, Walton, Tashfeen, Scholefield, Emma, Akram, Ahsan R., Walsh, Timothy S., Haslett, Chris, Bradley, Mark, Dhaliwal, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131393/
https://www.ncbi.nlm.nih.gov/pubmed/30201982
http://dx.doi.org/10.1038/s41598-018-31391-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131393/
https://www.ncbi.nlm.nih.gov/pubmed/30201982
http://dx.doi.org/10.1038/s41598-018-31391-9

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