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Ectopic expression of aPKC-mediated phosphorylation in p300 modulates hippocampal neurogenesis, CREB binding and fear memory differently with age

Epigenetic modifications have become an emerging interface that links extrinsic signals to alterations of gene expression that determine cell identity and function. However, direct signaling that regulates epigenetic modifications is unknown. Our previous work demonstrated that phosphorylation of CB...

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Detalles Bibliográficos
Autores principales: Syal, Charvi, Seegobin, Matthew, Sarma, Sailendra Nath, Gouveia, Ayden, Hsu, Karolynn, Niibori, Yosuke, He, Ling, Wondisford, Fredric E., Frankland, Paul W., Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131509/
https://www.ncbi.nlm.nih.gov/pubmed/30201979
http://dx.doi.org/10.1038/s41598-018-31657-2