Cytosolic Internalization of Anti-DNA Antibodies by Human Monocytes Induces Production of Pro-inflammatory Cytokines Independently of the Tripartite Motif-Containing 21 (TRIM21)-Mediated Pathway

Anti-DNA autoantibodies are a hallmark of systemic lupus erythematosus (SLE). A subset of anti-DNA IgG autoantibodies is cell-internalizable; thus they can enter living cells in the form of free IgG. However, the contribution made by the Fc region of internalized free-form IgG to the cytokine respon...

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Detalles Bibliográficos
Autores principales: Park, Hyunjoon, Kim, Minjae, Seo, Youngsil, Ham, Yeonkyoung, Cho, Mi-Young, Kwon, Myung-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131520/
https://www.ncbi.nlm.nih.gov/pubmed/30233598
http://dx.doi.org/10.3389/fimmu.2018.02019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131520/
https://www.ncbi.nlm.nih.gov/pubmed/30233598
http://dx.doi.org/10.3389/fimmu.2018.02019

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