Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to the respiratory chain by shuttling electrons to the ubiquinone pool. We have discovered ascofuranone (1), a natural compound p...

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Detalles Bibliográficos
Autores principales: Miyazaki, Yukiko, Inaoka, Daniel K., Shiba, Tomoo, Saimoto, Hiroyuki, Sakura, Takaya, Amalia, Eri, Kido, Yasutoshi, Sakai, Chika, Nakamura, Mari, Moore, Anthony L., Harada, Shigeharu, Kita, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131557/
https://www.ncbi.nlm.nih.gov/pubmed/30233375
http://dx.doi.org/10.3389/fphar.2018.00997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131557/
https://www.ncbi.nlm.nih.gov/pubmed/30233375
http://dx.doi.org/10.3389/fphar.2018.00997

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