Cargando…

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to the respiratory chain by shuttling electrons to the ubiquinone pool. We have discovered ascofuranone (1), a natural compound p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miyazaki, Yukiko, Inaoka, Daniel K., Shiba, Tomoo, Saimoto, Hiroyuki, Sakura, Takaya, Amalia, Eri, Kido, Yasutoshi, Sakai, Chika, Nakamura, Mari, Moore, Anthony L., Harada, Shigeharu, Kita, Kiyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131557/ https://www.ncbi.nlm.nih.gov/pubmed/30233375 http://dx.doi.org/10.3389/fphar.2018.00997

Ejemplares similares

Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target
por: Sato, Dan, et al.
Publicado: (2020)

Identification of 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase
por: Hartuti, Endah Dwi, et al.
Publicado: (2021)

Identification of Plasmodium falciparum Mitochondrial Malate: Quinone Oxidoreductase Inhibitors from the Pathogen Box
por: Wang, Xinying, et al.
Publicado: (2019)

Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors
por: Yamashita, Tetsuo, et al.
Publicado: (2018)

Discovery of New Class of Trypanocidal Compounds Targeting the Energy Metabolism of African Trypanosomes
por: Balogun, Emmanuel Oluwadare, et al.
Publicado: (2017)

Killing Two Birds with One Stone: Discovery of Dual Inhibitors of Oxygen and Fumarate Respiration in Zoonotic Parasite, Echinococcus multilocularis
por: Enkai, Shigehiro, et al.
Publicado: (2023)

Functional importance of Crenarchaea-specific extra-loop revealed by an X-ray structure of a heterotetrameric crenarchaeal splicing endonuclease
por: Yoshinari, Shigeo, et al.
Publicado: (2009)

Biochemical characterization and identification of ferulenol and embelin as potent inhibitors of malate:quinone oxidoreductase from Campylobacter jejuni
por: Kabongo, Augustin Tshibaka, et al.
Publicado: (2023)

Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum
por: Ross, Leila Saxby, et al.
Publicado: (2018)

Mysteries of partial dihydroorotate dehydrogenase inhibition and leukemia terminal differentiation
por: Saunthararajah, Yogen
Publicado: (2020)

Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase
por: Xu, Yechun, et al.
Publicado: (2020)

Identification of Dihydroorotate Dehydrogenase Inhibitors Using the Cell Painting Assay
por: Schölermann, Beate, et al.
Publicado: (2022)

Fluorescence assay of dihydroorotate dehydrogenase that may become a cancer biomarker
por: Yin, Sheng, et al.
Publicado: (2017)

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
por: Kokkonda, Sreekanth, et al.
Publicado: (2018)

Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines
por: Horwitz, Samantha M., et al.
Publicado: (2022)

Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
por: Houshmand, Mohammad, et al.
Publicado: (2022)

Novel Characteristics of Mitochondrial Electron Transport Chain from Eimeria tenella
por: Matsubayashi, Makoto, et al.
Publicado: (2019)

Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria
por: Inaoka, Daniel Ken, et al.
Publicado: (2015)

The ASCT/SCS cycle fuels mitochondrial ATP and acetate production in Trypanosoma brucei
por: Mochizuki, Kota, et al.
Publicado: (2020)

Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition
por: Arnould, Stéphanie, et al.
Publicado: (2017)

Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase
por: Maetani, Micah, et al.
Publicado: (2017)

Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma
por: Yu, Yajie, et al.
Publicado: (2021)

Combination of consensus and ensemble docking strategies for the discovery of human dihydroorotate dehydrogenase inhibitors
por: Chilingaryan, Garri, et al.
Publicado: (2021)

Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii
por: Russo, Thomas A., et al.
Publicado: (2022)

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors
por: Deng, Xiaoyi, et al.
Publicado: (2014)

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase
por: Costeira-Paulo, Joana, et al.
Publicado: (2018)

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells
por: Wu, Dang, et al.
Publicado: (2018)

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia
por: Zhou, Jianbiao, et al.
Publicado: (2019)

Molecular docking analysis of Plasmodium falciparum dihydroorotate dehydrogenase towards the design of effective inhibitors
por: Owoloye, Afolabi, et al.
Publicado: (2020)

Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study
por: Galati, Salvatore, et al.
Publicado: (2022)

The target site of the novel fungicide quinofumelin, Pyricularia oryzae class II dihydroorotate dehydrogenase
por: Higashimura, Norikazu, et al.
Publicado: (2022)

Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling
por: KAWATANI, MAKOTO, et al.
Publicado: (2023)

Siccanin Is a Dual-Target Inhibitor of Plasmodium falciparum Mitochondrial Complex II and Complex III
por: Komatsuya, Keisuke, et al.
Publicado: (2022)

The Role of Dihydroorotate Dehydrogenase in Apoptosis Induction in Response to Inhibition of the Mitochondrial Respiratory Chain Complex III
por: Khutornenko, A. A., et al.
Publicado: (2014)

Crystal structures of FMN‐bound and FMN‐free forms of dihydroorotate dehydrogenase from Trypanosoma brucei
por: Kubota, Tomomi, et al.
Publicado: (2018)

Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase
por: Dorasamy, Mathura Subangari, et al.
Publicado: (2017)

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro
por: Kim, Yu-Jin, et al.
Publicado: (2020)

Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
por: Branstrom, Arthur, et al.
Publicado: (2022)

Novel fungicide quinofumelin shows selectivity for fungal dihydroorotate dehydrogenase over the corresponding human enzyme
por: Higashimura, Norikazu, et al.
Publicado: (2023)

3D-QSAR Studies on a Series of Dihydroorotate Dehydrogenase Inhibitors: Analogues of the Active Metabolite of Leflunomide
por: Li, Shun-Lai, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_6u4a0cbtt12ib0hlpeqavu5k52