Pirfenidone suppresses TGF-β1-induced human intestinal fibroblasts activities by regulating proliferation and apoptosis via the inhibition of the Smad and PI3K/AKT signaling pathway

Intestinal fibroblasts, the main effector cells of intestinal fibrosis, are considered to be a good target for anti-fibrotic therapy. The aim of the present study was to examine the effects of pirfenidone (PFD) on human intestinal fibroblasts (HIFs) stimulated by transforming growth factor (TGF)-β1...

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Detalles Bibliográficos
Autores principales: Sun, Yanwu, Zhang, Yiyi, Chi, Pan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131636/
https://www.ncbi.nlm.nih.gov/pubmed/30152848
http://dx.doi.org/10.3892/mmr.2018.9423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131636/
https://www.ncbi.nlm.nih.gov/pubmed/30152848
http://dx.doi.org/10.3892/mmr.2018.9423

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