FAF1 mediates necrosis through JNK1-mediated mitochondrial dysfunction leading to retinal degeneration in the ganglion cell layer upon ischemic insult

BACKGROUND: Aberrant cell death induced by ischemic stress is implicated in the pathogenesis of ischemic diseases. Fas-associated factor 1 (FAF1) has been identified as a death-promoting protein. This study demonstrates that FAF1 functions in death signaling triggered by ischemic insult. METHODS: Th...

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Detalles Bibliográficos
Autores principales: Yu, Changsun, Kim, Bok-seok, Park, Minyoung, Do, Yun-Ju, Kong, Young-Yun, Kim, Eunhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131785/
https://www.ncbi.nlm.nih.gov/pubmed/30200976
http://dx.doi.org/10.1186/s12964-018-0265-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131785/
https://www.ncbi.nlm.nih.gov/pubmed/30200976
http://dx.doi.org/10.1186/s12964-018-0265-7

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