Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis

Neurotropic strains of mouse hepatitis virus (MHV) induce acute inflammation and chronic demyelination in the spinal cord and optic nerves mediated by axonal spread following intracranial inoculation in mice, with pathologic features similar to the human demyelinating disease multiple sclerosis. Spi...

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Detalles Bibliográficos
Autores principales: Singh, Manmeet, Khan, Reas S., Dine, Kimberly, Das Sarma, Jayasri, Shindler, Kenneth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132074/
https://www.ncbi.nlm.nih.gov/pubmed/30234031
http://dx.doi.org/10.3389/fcimb.2018.00311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132074/
https://www.ncbi.nlm.nih.gov/pubmed/30234031
http://dx.doi.org/10.3389/fcimb.2018.00311

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