Insulin down-regulates cardioprotective SUR2A in the heart-derived H9c2 cells: A possible explanation for some adverse effects of insulin therapy

Some recent studies associated insulin therapy with negative cardiovascular events and shorter lifespan. SUR2A, a K(ATP) channel subunit, regulate cardioprotection and cardiac ageing. Here, we have tested whether glucose and insulin regulate expression of SUR2A/K(ATP) channel subunits and resistance...

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Detalles Bibliográficos
Autores principales: Du, Qingyou, Jovanović, Sofija, Sukhodub, Andriy, Ngoi, Yong Shi, Lal, Aashray, Zheleva, Marina, Jovanović, Aleksandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132176/
https://www.ncbi.nlm.nih.gov/pubmed/30211323
http://dx.doi.org/10.1016/j.bbrep.2018.08.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132176/
https://www.ncbi.nlm.nih.gov/pubmed/30211323
http://dx.doi.org/10.1016/j.bbrep.2018.08.005

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