Treosulfan Pharmacokinetics and its Variability in Pediatric and Adult Patients Undergoing Conditioning Prior to Hematopoietic Stem Cell Transplantation: Current State of the Art, In-Depth Analysis, and Perspectives

Treosulfan is a prodrug that undergoes a highly pH- and temperature-dependent nonenzymatic conversion to the monoepoxide {(2S,3S)-1,2-epoxy-3,4-butanediol 4-methanesulfonate [S,S-EBDM]} and diepoxide {(2S,3S)-1,2:3,4-diepoxybutane [S,S-DEB]}. Currently, treosulfan is tested in clinical trials as an...

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Detalles Bibliográficos
Autores principales: Romański, Michał, Wachowiak, Jacek, Główka, Franciszek K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132445/
https://www.ncbi.nlm.nih.gov/pubmed/29557088
http://dx.doi.org/10.1007/s40262-018-0647-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132445/
https://www.ncbi.nlm.nih.gov/pubmed/29557088
http://dx.doi.org/10.1007/s40262-018-0647-4

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