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Kinetics and Characterization of Degradation Products of Dihydralazine and Hydrochlorothiazide in Binary Mixture by HPLC-UV, LC-DAD and LC–MS Methods

Dihydralazine and hydrochlorothiazide were stored at high temperature and humidity, under UV/Vis light and different pH, as individual drugs and the mixture. Then, a sensitive and selective HPLC-UV method was developed for simultaneous determination of dihydralazine and hydrochlorothiazide in presen...

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Detalles Bibliográficos
Autores principales: Gumieniczek, Anna, Galeza, Justyna, Mroczek, Tomasz, Wojtanowski, Krzysztof, Lipska, Katarzyna, Pietras, Rafał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132553/
https://www.ncbi.nlm.nih.gov/pubmed/30220731
http://dx.doi.org/10.1007/s10337-018-3555-8