Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds

Safety assessment of drug candidates in numerous in vitro and experimental animal models is expensive, time consuming and animal intensive. More thorough toxicity profiling already in the early drug discovery projects using human cell models, which more closely resemble the physiological cell types,...

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Detalles Bibliográficos
Autores principales: Karhu, S. Tuuli, Välimäki, Mika J., Jumppanen, Mikael, Kinnunen, Sini M., Pohjolainen, Lotta, Leigh, Robert S., Auno, Samuli, Földes, Gábor, Boije af Gennäs, Gustav, Yli-Kauhaluoma, Jari, Ruskoaho, Heikki, Talman, Virpi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132687/
https://www.ncbi.nlm.nih.gov/pubmed/29987409
http://dx.doi.org/10.1007/s00204-018-2257-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132687/
https://www.ncbi.nlm.nih.gov/pubmed/29987409
http://dx.doi.org/10.1007/s00204-018-2257-1

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