Digital microfluidic immobilized cytochrome P450 reactors with integrated inkjet-printed microheaters for droplet-based drug metabolism research

We report the development and characterization of digital microfluidic (DMF) immobilized enzyme reactors (IMERs) for studying cytochrome P450 (CYP)-mediated drug metabolism on droplet scale. The on-chip IMERs consist of porous polymer (thiol-ene) monolith plugs prepared in situ by photopolymerizatio...

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Detalles Bibliográficos
Autores principales: Sathyanarayanan, Gowtham, Haapala, Markus, Kiiski, Iiro, Sikanen, Tiina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132693/
https://www.ncbi.nlm.nih.gov/pubmed/30073515
http://dx.doi.org/10.1007/s00216-018-1280-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132693/
https://www.ncbi.nlm.nih.gov/pubmed/30073515
http://dx.doi.org/10.1007/s00216-018-1280-7

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