Pharmacodynamic modelling of resistance to epidermal growth factor receptor inhibition in brain metastasis mouse models

PURPOSE: Epidermal growth factor receptor (EGFR) is thought to play a role in the regulation of cell proliferation; with its activation stimulating tumour growth. EGFR inhibitors have shown promise in the treatment of cancer, particularly in non-small cell lung cancer, however, resistance is observe...

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Detalles Bibliográficos
Autores principales: Martin, Emma C., Aarons, Leon, Yates, James W. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132866/
https://www.ncbi.nlm.nih.gov/pubmed/30054711
http://dx.doi.org/10.1007/s00280-018-3630-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132866/
https://www.ncbi.nlm.nih.gov/pubmed/30054711
http://dx.doi.org/10.1007/s00280-018-3630-8

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