NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study

BACKGROUND: Despite NUDT15 variants showing significant association with thiopurine-induced adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or whether additional genetic variants should be tested to predict AEs. To clarify the best pharmacogenetic test to be used clinical...

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Detalles Bibliográficos
Autores principales: Kakuta, Yoichi, Kawai, Yosuke, Okamoto, Daisuke, Takagawa, Tetsuya, Ikeya, Kentaro, Sakuraba, Hirotake, Nishida, Atsushi, Nakagawa, Shoko, Miura, Miki, Toyonaga, Takahiko, Onodera, Kei, Shinozaki, Masaru, Ishiguro, Yoh, Mizuno, Shinta, Takahara, Masahiro, Yanai, Shunichi, Hokari, Ryota, Nakagawa, Tomoo, Araki, Hiroshi, Motoya, Satoshi, Naito, Takeo, Moroi, Rintaro, Shiga, Hisashi, Endo, Katsuya, Kobayashi, Taku, Naganuma, Makoto, Hiraoka, Sakiko, Matsumoto, Takayuki, Nakamura, Shiro, Nakase, Hiroshi, Hisamatsu, Tadakazu, Sasaki, Makoto, Hanai, Hiroyuki, Andoh, Akira, Nagasaki, Masao, Kinouchi, Yoshitaka, Shimosegawa, Tooru, Masamune, Atsushi, Suzuki, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2018
Materias:
Original Article—Alimentary Tract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132901/
https://www.ncbi.nlm.nih.gov/pubmed/29923122
http://dx.doi.org/10.1007/s00535-018-1486-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132901/
https://www.ncbi.nlm.nih.gov/pubmed/29923122
http://dx.doi.org/10.1007/s00535-018-1486-7

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