Effects of Ketoconazole and Rifampicin on the Pharmacokinetics of Nintedanib in Healthy Subjects

BACKGROUND: Nintedanib is a substrate for p-glycoprotein which can impact bioavailability. We investigated the effects of ketoconazole, a p-glycoprotein inhibitor, and rifampicin, a p-glycoprotein inducer, on the pharmacokinetics of nintedanib. METHODS: In the ketoconazole study, 34 healthy subjects...

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Detalles Bibliográficos
Autores principales: Luedtke, Doreen, Marzin, Kristell, Jungnik, Arvid, von Wangenheim, Ute, Dallinger, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133080/
https://www.ncbi.nlm.nih.gov/pubmed/29500603
http://dx.doi.org/10.1007/s13318-018-0467-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133080/
https://www.ncbi.nlm.nih.gov/pubmed/29500603
http://dx.doi.org/10.1007/s13318-018-0467-9

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