Thiazoles with cyclopropyl fragment as antifungal, anticonvulsant, and anti-Toxoplasma gondii agents: synthesis, toxicity evaluation, and molecular docking study

Synthesis and investigation of antifungal, anticonvulsant and anti-Toxoplasma gondii activities of ten novel (2-(cyclopropylmethylidene)hydrazinyl)thiazole 3a–3j are presented. Among the derivatives, compounds 3a–3d and 3f–3j possess very high activity against Candida spp. ATCC with MIC = 0.015–7.81...

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Detalles Bibliográficos
Autores principales: Łączkowski, Krzysztof Z., Konklewska, Natalia, Biernasiuk, Anna, Malm, Anna, Sałat, Kinga, Furgała, Anna, Dzitko, Katarzyna, Bekier, Adrian, Baranowska-Łączkowska, Angelika, Paneth, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133161/
https://www.ncbi.nlm.nih.gov/pubmed/30220831
http://dx.doi.org/10.1007/s00044-018-2221-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133161/
https://www.ncbi.nlm.nih.gov/pubmed/30220831
http://dx.doi.org/10.1007/s00044-018-2221-x

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