CRISPR/Cas9 gene editing for the creation of an MGAT1-deficient CHO cell line to control HIV-1 vaccine glycosylation

Over the last decade, multiple broadly neutralizing monoclonal antibodies (bN-mAbs) to the HIV-1 envelope protein (Env) gp120 have been described. Many of these recognize epitopes consisting of both amino acid and glycan residues. Moreover, the glycans required for binding of these bN-mAbs are early...

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Detalles Bibliográficos
Autores principales: Byrne, Gabriel, O’Rourke, Sara M., Alexander, David L., Yu, Bin, Doran, Rachel C., Wright, Meredith, Chen, Qiushi, Azadi, Parastoo, Berman, Phillip W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Methods and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133382/
https://www.ncbi.nlm.nih.gov/pubmed/30157178
http://dx.doi.org/10.1371/journal.pbio.2005817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133382/
https://www.ncbi.nlm.nih.gov/pubmed/30157178
http://dx.doi.org/10.1371/journal.pbio.2005817

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