Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction

We recently reported that R-spondin 2 (Rspo2), a secreted activator of Wnt/β-catenin signaling, promotes acetylcholine receptor (AChR) clustering and neuromuscular junction (NMJ) formation via its receptor, Lgr5. Rspo2 is expressed highly in spinal motor neurons (SMNs) and marginally in the skeletal...

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Detalles Bibliográficos
Autores principales: Li, Jin, Ito, Mikako, Ohkawara, Bisei, Masuda, Akio, Ohno, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133930/
https://www.ncbi.nlm.nih.gov/pubmed/30206360
http://dx.doi.org/10.1038/s41598-018-31949-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133930/
https://www.ncbi.nlm.nih.gov/pubmed/30206360
http://dx.doi.org/10.1038/s41598-018-31949-7

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