The voltage-dependence of MscL has dipolar and dielectric contributions and is governed by local intramembrane electric field

Channels without canonical voltage sensors can be modulated by voltage acting on other domains. Here we show that besides protein dipoles, pore hydration can be affected by electric fields. In patches, both WT MscL and its V23T mutant show a decrease in the tension midpoint with hyperpolarization. T...

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Detalles Bibliográficos
Autores principales: Najem, Joseph S., Rowe, Ian, Anishkin, Andriy, Leo, Donald J., Sukharev, Sergei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133944/
https://www.ncbi.nlm.nih.gov/pubmed/30206263
http://dx.doi.org/10.1038/s41598-018-31945-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133944/
https://www.ncbi.nlm.nih.gov/pubmed/30206263
http://dx.doi.org/10.1038/s41598-018-31945-x

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