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The voltage-dependence of MscL has dipolar and dielectric contributions and is governed by local intramembrane electric field
Channels without canonical voltage sensors can be modulated by voltage acting on other domains. Here we show that besides protein dipoles, pore hydration can be affected by electric fields. In patches, both WT MscL and its V23T mutant show a decrease in the tension midpoint with hyperpolarization. T...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133944/ https://www.ncbi.nlm.nih.gov/pubmed/30206263 http://dx.doi.org/10.1038/s41598-018-31945-x |