Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

Genome damage and defective repair are etiologically linked to neurodegeneration. However, the specific mechanisms involved remain enigmatic. Here, we identify defects in DNA nick ligation and oxidative damage repair in a subset of amyotrophic lateral sclerosis (ALS) patients. These defects are caus...

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Detalles Bibliográficos
Autores principales: Wang, Haibo, Guo, Wenting, Mitra, Joy, Hegde, Pavana M., Vandoorne, Tijs, Eckelmann, Bradley J., Mitra, Sankar, Tomkinson, Alan E., Van Den Bosch, Ludo, Hegde, Muralidhar L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134028/
https://www.ncbi.nlm.nih.gov/pubmed/30206235
http://dx.doi.org/10.1038/s41467-018-06111-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134028/
https://www.ncbi.nlm.nih.gov/pubmed/30206235
http://dx.doi.org/10.1038/s41467-018-06111-6

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