Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope

Only one naturally occurring human antibody has been described thus far that is capable of potently neutralizing all five ebolaviruses. Here we present two crystal structures of this rare, pan-ebolavirus neutralizing human antibody in complex with Ebola virus and Bundibugyo virus glycoproteins (GPs)...

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Detalles Bibliográficos
Autores principales: West, Brandyn R., Moyer, Crystal L., King, Liam B., Fusco, Marnie L., Milligan, Jacob C., Hui, Sean, Saphire, Erica Ollmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134094/
https://www.ncbi.nlm.nih.gov/pubmed/30206174
http://dx.doi.org/10.1128/mBio.01674-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134094/
https://www.ncbi.nlm.nih.gov/pubmed/30206174
http://dx.doi.org/10.1128/mBio.01674-18

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