Cargando…

Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope

Only one naturally occurring human antibody has been described thus far that is capable of potently neutralizing all five ebolaviruses. Here we present two crystal structures of this rare, pan-ebolavirus neutralizing human antibody in complex with Ebola virus and Bundibugyo virus glycoproteins (GPs)...

Descripción completa

Detalles Bibliográficos
Autores principales:	West, Brandyn R., Moyer, Crystal L., King, Liam B., Fusco, Marnie L., Milligan, Jacob C., Hui, Sean, Saphire, Erica Ollmann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134094/ https://www.ncbi.nlm.nih.gov/pubmed/30206174 http://dx.doi.org/10.1128/mBio.01674-18

Ejemplares similares

Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody
por: West, Brandyn R., et al.
Publicado: (2019)

Structural Basis for Differential Neutralization of Ebolaviruses
por: Bale, Shridhar, et al.
Publicado: (2012)

Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
por: King, Liam B., et al.
Publicado: (2019)

A Shared Structural Solution for Neutralizing Ebolaviruses
por: Dias, João M., et al.
Publicado: (2011)

Pan-ebolavirus serology study of healthcare workers in the Mbandaka Health Region, Democratic Republic of the Congo
por: Shaffer, Kelly C. L., et al.
Publicado: (2022)

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein
por: Gilchuk, Pavlo, et al.
Publicado: (2018)

133 Structural basis for ebolavirus matrix assembly and budding; protein plasticity allows multiple functions
por: Bornholdt, Zachary, et al.
Publicado: (2014)

Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors
por: Bramble, Matthew S, et al.
Publicado: (2018)

Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment
por: Landeras-Bueno, Sara, et al.
Publicado: (2019)

Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a Pan-Ebolavirus Immunotherapeutic
por: Kuang, Erin, et al.
Publicado: (2022)

Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development
por: Murin, Charles D., et al.
Publicado: (2022)

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization
por: Gilchuk, Pavlo, et al.
Publicado: (2020)

Discovery of an antibody for pan-ebolavirus therapy
por: Furuyama, Wakako, et al.
Publicado: (2016)

Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop
por: Janus, Benjamin M., et al.
Publicado: (2018)

Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope
por: Austin, S. Kyle, et al.
Publicado: (2012)

Structure of the Reston ebolavirus VP30 C-terminal domain
por: Clifton, Matthew C., et al.
Publicado: (2014)

Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus
por: Howell, Katie A., et al.
Publicado: (2017)

The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis
por: Kirchdoerfer, Robert N., et al.
Publicado: (2016)

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies
por: Bornholdt, Zachary A., et al.
Publicado: (2016)

Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma
por: Gilchuk, Pavlo, et al.
Publicado: (2021)

Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes
por: Chen, Elaine C., et al.
Publicado: (2023)

Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease
por: Hastie, Kathryn M., et al.
Publicado: (2012)

In Silico Analyses, Experimental Verification and Application in DNA Vaccines of Ebolavirus GP-Derived pan-MHC-II-Restricted Epitopes
por: Zhang, Junqi, et al.
Publicado: (2023)

Glycan shield of the ebolavirus envelope glycoprotein GP
por: Peng, Weiwei, et al.
Publicado: (2022)

Conservancy of mAb Epitopes in Ebolavirus Glycoproteins of Previous and 2014 Outbreaks
por: Ponomarenko, Julia, et al.
Publicado: (2014)

Ebola Virus Glycoprotein Needs an Additional Trigger, beyond Proteolytic Priming for Membrane Fusion
por: Bale, Shridhar, et al.
Publicado: (2011)

Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity
por: Jensen, Jaime L., et al.
Publicado: (2023)

Characterization of Antigenic MHC-Class-I-Restricted T Cell Epitopes in the Glycoprotein of Ebolavirus
por: Powlson, Jonathan, et al.
Publicado: (2019)

Ebolavirus Database: Gene and Protein Information Resource for Ebolaviruses
por: Swetha, Rayapadi G., et al.
Publicado: (2016)

Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope
por: Torralba, Johana, et al.
Publicado: (2022)

Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region
por: Schoeder, Clara T., et al.
Publicado: (2022)

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit
por: Hurlburt, Nicholas K., et al.
Publicado: (2022)

Assembly and Budding of Ebolavirus
por: Noda, Takeshi, et al.
Publicado: (2006)

Ebolavirus comparative genomics
por: Jun, Se-Ran, et al.
Publicado: (2015)

Ebolavirus and Other Filoviruses
por: Leroy, E., et al.
Publicado: (2007)

Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies
por: Murin, Charles D., et al.
Publicado: (2021)

How can cryptic epitopes trigger autoimmunity?
Publicado: (1995)

Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III
por: Wu, Yanling, et al.
Publicado: (2017)

Ebolavirus Evolution: Past and Present
por: de La Vega, Marc-Antoine, et al.
Publicado: (2015)

Virological diagnosis of Ebolavirus infection
por: Smith, D. W., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_054rrlrpf42kqd8j8srcujckl6